abstract：:Methotrexate (50 mg/m2 intramuscularly and 50 mg orally) followed by vaginal misoprostol have proven to be > 90% effective at causing abortion in women at less than 49 days' gestation. Although the effectiveness of the oral dose (which has a lower serum bioavailability) demonstrates that a methotrexate dose of 50 mg/m...

journal_title：Contraception

authors： Creinin MD

更新日期：1997-12-01 00:00:00

abstract：:Forty-three homozygous (SS) female sickle cell anemic patients with a history of at least one painful crisis per month and desiring a reversible contraceptive were administered DMPA/3 months or Microgynon monthly. A third group of 16 surgically sterilized patients served as control. Patients were followed for 1 year t...

journal_title：Contraception

authors： de Abood M,de Castillo Z,Guerrero F,Espino M,Austin KL

更新日期：1997-11-01 00:00:00

abstract：:A 1-year longitudinal multicenter study was undertaken to monitor the effects on lipid metabolism of two once-a-month injectable contraceptive preparations, Mesigyna (50 mg norethisterone enanthate and 5 mg estradiol valerate and Cyclofem (25 mg medroxyprogesterone acetate and 5 mg estradiol cypionate). A total of 357...

journal_title：Contraception

authors：

更新日期：1997-10-01 00:00:00

abstract：:The aim of this study was to determine the effect of a short-term ethinyl estradiol/levonorgestrel medication on blood flow in the uterine arteries in postmenopausal women in a prospective placebo-controlled double-blind study. Twenty-one healthy postmenopausal woman at least 2 years after menopause received 60 microg...

journal_title：Contraception

authors： Entezami M,Heger-Mahn D,Ebert A,Halis G,Lübbert H

更新日期：1997-09-01 00:00:00

abstract：:The objectives of the study were to assess the ability of the Femcap, a new vaginal contraceptive device made of silicone and designed to fit snugly around the cervix to prevent the penetration of sperm into midcycle cervical mucus when used with and without spermicide; and to compare it with the standard contraceptiv...

journal_title：Contraception

authors： Mauck CK,Baker JM,Barr SP,Johanson W,Archer DF

更新日期：1997-08-01 00:00:00

abstract：:The objectives of this study were to define the "normal" position of the T-shaped intrauterine device (IUD) in the endometrial cavity, using transvaginal ultrasound, and to compare the IUD's position in women with and without complaints of bleeding and/or pain. Vaginal ultrasound was carried out in women who had used ...

journal_title：Contraception

authors： Faúndes D,Bahamondes L,Faúndes A,Petta C,Díaz J,Marchi N

更新日期：1997-07-01 00:00:00

abstract：:The study of a modified minilaparotomy technique of interval female sterilization is reported. The modified minilaparotomy technique of interval female sterilization is performed under local anesthesia using the Ramathibodi uterine manipulator, bivalve speculum, and a low midline incision. Sixty cases were treated wit...

journal_title：Contraception

authors： Taneepanichskul S,Intaraprasert S,Chaturachinda K

更新日期：1997-06-01 00:00:00

abstract：:The mechanism of copper in limiting intrauterine infections in intrauterine device (Cu IUD) users is poorly understood. Copper ions may enhance the release of reactive oxygen radicals, which in turn decrease the release of reactive nitrogen intermediates (RNI). RNI are known to have bactericidal effect. The present st...

journal_title：Contraception

authors： Pradhan M,Gupta I,Ganguli NK

更新日期：1997-05-01 00:00:00

abstract：:In a case-control study of 1647 breast cancer cases and 1501 population controls under 45 years of age, potential modifying effects of other risk factors on the relationship of oral contraceptives to breast cancer were examined. Among the total series of study subjects, the relationship of extended pill usage was grea...

journal_title：Contraception

authors： Brinton LA,Gammon MD,Malone KE,Schoenberg JB,Daling JR,Coates RJ

更新日期：1997-04-01 00:00:00

abstract：:The aim of this study was to compare contraceptive reliability, cycle control, and tolerance of an oral contraceptive containing 20 micrograms ethinylestradiol (EE2) and 75 micrograms gestodene (GSD), with a reference preparation containing a similar dose of gestodene but in combination with 30 micrograms ethinylestra...

journal_title：Contraception

authors： Endrikat J,Müller U,Düsterberg B

更新日期：1997-03-01 00:00:00

abstract：:The use of mifepristone as an anti-implantation agent in the primate has been explored in the rhesus monkey with two specific aims: (i) to determine the contraceptive efficacy of very low-dose mifepristone administered on mated cycle days 16, 17, and 18; and (ii) to test the hypothesis that alteration in endometrial p...

journal_title：Contraception

authors： Nayak NR,Ghosh D,Lasley BL,Sengupta J

更新日期：1997-02-01 00:00:00

abstract：:After exposure of young male rats to gossypol acetic acid for various times, a reduction in the content of cellular and microtubular beta-tubulin was found in spermatocytes and spermatids. The content of tubulin was measured by enzyme-linked immunosorbent assay (ELISA). The results were expressed as micrograms tubulin...

journal_title：Contraception

authors： Teng CS

更新日期：1997-01-01 00:00:00

abstract：:The relationship between intrauterine device (IUD) use and the development of endometrial cancer was assessed in data from seven countries that were collected between 1979 and 1988 for a multinational hospital-based case-control study. Two hundred twenty-six cases of endometrial cancer were compared with 1,529 control...

journal_title：Contraception

authors： Rosenblatt KA,Thomas DB

更新日期：1996-12-01 00:00:00

abstract：:With the objective of evaluating the ovulatory function among long-term Norplant implants users with regular menstrual cycles, we undertook this prospective study including 11 Norplant implants users and 11 control women who were not using hormonal methods of fertility control. Exposed and unexposed women had had at l...

journal_title：Contraception

authors： Alvarez F,Brache V,Faundes A,Tejada AS,Thevenin F

更新日期：1996-11-01 00:00:00

abstract：:Effect of antiestrogen ormeloxifene on progesterone-induced development of giant mitochondria in uterine glandular epithelial cells in ovariectomized adult Sprague-Dawley rats was investigated. Antiestrogen tamoxifen and antiprogestin onapristone were used for comparison. Well-formed giant mitochondria were observed i...

journal_title：Contraception

authors： Chauhan SC,Singh MM,Maitra SC,Kamboj VP

更新日期：1996-10-01 00:00:00

abstract：:To determine the safety of transcervical administration of quinacrine pellets as a method of voluntary female sterilization, three noncomparative Phase I clinical trials of the administration of 250 mg quinacrine were carried out in 21 women who were scheduled to undergo hysterectomy 24 h or one month later. Detailed ...

journal_title：Contraception

authors： Laufe LE,Sokal DC,Cole LP,Shoupe D,Schenken RS

更新日期：1996-09-01 00:00:00

abstract：:New studies linking use of oral contraceptives (OCs) containing a third generation progestogen with venous thromboembolism (VTE) have stirred controversy. Epidemiologists face the task of separating a direct effect of the OC from the confounding effect of a pre-existing factor (e.g., smoking). Only 1-2% of VTE cases...

journal_title：Contraception

authors： Westhoff CL

更新日期：1996-07-01 00:00:00

abstract：:We analyzed data from 4,905 women aged 20-39 and 14,803 aged 40-49 who attended a health survey in Norway 1985-88, to study cardiovascular risk factors in users of oral contraceptives, all types and specifically by formulation. In age group 20-39, users of low-dose estrogen/ progestin regimens were younger, had lower ...

journal_title：Contraception

authors： Graff-Iversen S,Tverdal A,Stensvold I

更新日期：1996-06-01 00:00:00

abstract：:This study was designed to investigate the effects of repeated high doses of an LHRH agonist on Swiss porton mouse seminiferous epithelium. Seminiferous epithelium showed more pronounced degenerative effects at the higher dose (1000 micrograms/kg wt/day) of the drug, with arrest of spermatogenesis at all stages of dif...

journal_title：Contraception

authors： Kher R,Kalla NR

更新日期：1996-05-01 00:00:00

abstract：:Condoms from five manufacturers were subjected to controlled exposures of heat, humidity, and air and to different natural environments in five countries. Under aerobic conditions (condoms in permeable packages or unpackaged), stress properties declined. The relationship between rate of decline as a function of temper...

journal_title：Contraception

authors： Free MJ,Srisamang V,Vail J,Mercer D,Kotz R,Marlowe DE

更新日期：1996-04-01 00:00:00

abstract：:Deeply inserted, nonpalpable contraceptive implants can often be removed easily using 6-8 cm3 of 1% lidocaine and a single 1 cm incision. There is no need for suturing of the incision. The location of nonpalpable implants not retrieved by this procedure can be determined by a plain, soft tissue x-ray (standard AP and ...

journal_title：Contraception

authors： Sarma SP,Wamsher JG,Whitlock SW

更新日期：1996-03-01 00:00:00

abstract：:Uniplant, a single Silastic implant containing nomegestrol acetate, provides contraceptive efficacy for one year. Uniplant use for one year was studied in 1,803 healthy women of reproductive age, enrolled from 10 centers in 9 countries, after informed consent. Implants were placed subdermally either in the upper arm o...

journal_title：Contraception

authors： Coutinho EM,de Souza JC,Athayde C,Barbosa IC,Alvarez F,Brache V,Gu ZP,Emuveyan EE,Adekunle AO,Devoto L,Shaaban MM,Salem HT,Affandi B,de Acosta OM,Mati J,Ladipo OA

更新日期：1996-02-01 00:00:00

abstract：:To describe surface abnormalities found by scanning electron microscopy of non-lubricated latex condoms, thirty samples of 15 condoms were photographed at low (26-94x), medium (240-940x) and high (> 1000x) magnification. Each sample was initially scanned at low magnification to determine the presence and location of s...

journal_title：Contraception

authors： Rosenzweig BA,Even A,Budnick LE

更新日期：1996-01-01 00:00:00

abstract：:A placebo-controlled, double-blind study was carried out to assess the direct hormonal effects of combined and progestogen-only oral contraceptives on well-being and sexuality of women in two contrasting cultures. One-hundred-fifty women, who had been sterilised or whose partners had been vasectomised, were recruited ...

journal_title：Contraception

authors： Graham CA,Ramos R,Bancroft J,Maglaya C,Farley TM

更新日期：1995-12-01 00:00:00

abstract：:Mature epididymal boar spermatozoa converted fructose, glycerol and glycerol-3-phosphate to carbon dioxide, but in the presence of 0.5 mM 3-bromopyruvate, these oxidations were inhibited while that of lactate was unaffected. Inhibition of the oxidation of these substrates results in a decrease in the content of ATP an...

journal_title：Contraception

authors： Jones AR,Gillan L,Milmlow D

更新日期：1995-11-01 00:00:00

abstract：:In 1991, the source of public sector condom supplies in an African country changed from USAID to WHO. Following a complaint, the two types of condoms were sampled and compared. Laboratory tests indicated that the new-style condoms were of adequate quality, but a number of differences were noted between the two types. ...

journal_title：Contraception

authors： Gerofi J,Deniaud F,Friel P

更新日期：1995-10-01 00:00:00

abstract：:This study is concerned with contraceptive use among the currently married adolescents in Bangladesh utilizing the 1989 Bangladesh Fertility Survey (BFS) data. The study analyzes the factors affecting the current use of contraception among the adolescents through bivariate and multivariate logistic regression analysis...

journal_title：Contraception

authors： Mahmud M,Islam MM

更新日期：1995-09-01 00:00:00

abstract：:This article reports the effects of gossypol at the genomic level in rat spermatogenic cells. After gossypol treatment for various times (8, 12, and 19 weeks), the spermatogonial cells were allowed to rest for 2 to 4 weeks. The function of histone H4 gene promoter (H4GP) in the repopulating pachytene spermatocytes (RP...

journal_title：Contraception

authors： Teng CS,Yang NY,Chen Y

更新日期：1995-08-01 00:00:00

abstract：:The clinical performance of the Copper T 380A (TCu 380A) and the Lippes Loop intrauterine devices (IUDs) were evaluated for 12 months in a group of 710 women who had one of the two IUDs inserted. Results are from a randomized clinical trial conducted at three collaborating research sites located in three developing co...

journal_title：Contraception

authors： Farr G,Amatya R,Acosta M,Ekwempu C,Kisninci H

更新日期：1995-07-01 00:00:00

abstract：:Combined oral contraceptives are undoubtedly popular. By the end of the 1980's, an estimated 63 million married women around the world were using this method of contraception. In Britain, perhaps 95% of all sexually active women have used the pill at some time before their 30th birthday. Commensurate with such widespr...

journal_title：Contraception

authors： Hannaford PC

更新日期：1995-06-01 00:00:00

abstract：:The opinions of 20 international experts in reproductive endocrinology and family planning service delivery were solicited concerning contraceptive pill use during breastfeeding and, in particular, to determine whether the experts felt that breastfeeding women who use progestin-only pills (POPs) should be advised to s...

journal_title：Contraception

authors： Visness CM,Rivera R

更新日期：1995-05-01 00:00:00

abstract：:Copper-bearing intrauterine contraceptive devices (IUCD) are commonly associated with menorrhagia. They cause certain morphological changes in the endometrium. These have been extensively reported and the mechanisms of menorrhagia have been investigated in a number of studies. By contrast, ovulatory dysfunctional uter...

journal_title：Contraception

authors： Wang IY,Russell P,Fraser IS

更新日期：1995-04-01 00:00:00

abstract：:The mode of antifertility action of intrauterine neem treatment (IUNT) was studied. The effect of IUNT on ovarian functions and uterine responsiveness to ovarian hormones was examined in adult Wistar rats. The treated animals had normal reproductive cycles as indicated by the vaginal smears; serum progesterone levels ...

journal_title：Contraception

authors： Kaushic C,Upadhyay S

更新日期：1995-03-01 00:00:00

abstract：:The discovery of the reversible antifertility action of an extract from Tripterygium wilfordii both in male rats and in men in 1986 stimulated worldwide interest. International and national collaborations aimed at the bioassay-directed sub-fractionation of materials extracted from the plant was then organized and to d...

journal_title：Contraception

authors： Zhen QS,Ye X,Wei ZJ

更新日期：1995-02-01 00:00:00

abstract：:The relationship of depot-medroxyprogesterone acetate (D-MPA) use to risk of cervical carcinoma in situ was investigated using data from a large multi-national, hospital-based case-control study. To avoid possible detection bias from Pap smear screening, final analyses were restricted to a subset of cases with symptom...

journal_title：Contraception

authors： Thomas DB,Ye Z,Ray RM

更新日期：1995-01-01 00:00:00

abstract：:The use of multiple clips for the occlusion of the Fallopian tubes has been reported in interval laparoscopic sterilization, but the circumstances leading to the performance of the multiple-clip procedure and its effects on safety and efficacy have not been carefully studied. A data set from international multi-center...

journal_title：Contraception

authors： Chi IC

更新日期：1994-11-01 00:00:00

abstract：:The efficacy of administering an antibiotic prior to IUD insertion to reduce the risk of introducing an upper genital tract infection during the procedure has not yet been established. Two double-blind randomized studies conducted in Africa comparing a 200 mg prophylactic dose of doxycycline with a placebo did not con...

journal_title：Contraception

authors： Walsh TL,Bernstein GS,Grimes DA,Frezieres R,Bernstein L,Coulson AH

更新日期：1994-10-01 00:00:00

abstract：:Seventy-five women with a mean age of 27.5 years who requested Norplant implants for contraception were studied over a five-year period. The patients kept daily diaries of their vaginal bleeding and coital frequency, and were seen at least every six months at which time their weight was measured. This study examines t...

journal_title：Contraception

authors： Pasquale SA,Knuppel RA,Owens AG,Bachmann GA

更新日期：1994-08-01 00:00:00

abstract：:A five-year study of NORPLANT II rod implants was undertaken in four large cities and metropolitan areas in eastern China. Designed to test the safety, efficacy and acceptability of these implants, the study involved 1,208 women and was conducted concurrently with a similar study of NORPLANT capsule implants. At the e...

journal_title：Contraception

authors： Gu S,Du M,Zhang L,Liu Y,Wang S,Sivin I

更新日期：1994-07-01 00:00:00

abstract：:Two-hundred-eight women attending family planning clinics in New York City who received the Norplant contraceptive system during the first sixteen months of Norplant implants insertions were evaluated. Within this clinic population, Norplant implants were a popular contraceptive choice and were removed from 64 of the ...

journal_title：Contraception

authors： Gerber S,Westhoff C,Lopez M,Gordon L

更新日期：1994-06-01 00:00:00